Five signaling-cascade panels — every biomarker orderable today through standard reference labs. Map the network that drives the disease before it names itself.
Single draw · verify availability in your service area
Conventional labs read organs in isolation. SignalOME reads the signaling pattern upstream — the cascade that decides how the organ behaves.
A single blood draw at any patient service center, plus a salivary kit where a panel calls for it.
Each biomarker is mapped to its signaling network and read against optimization targets — tighter than the population reference range.
Your clinician selects high-leverage interventions that act on the dysregulated cascade — often hitting several networks at once.
Each panel below is built entirely from biomarkers you can order through a standard reference lab — no specialty send-outs required. Order codes shown for the draw; verify for your service area before ordering.
The nutrient and insulin sensor. Hyperactive in insulin resistance, metabolic syndrome and NAFLD — the anabolic pressure behind metabolic disease.
The energy-deficit sensor that opposes mTOR and drives autophagy — read alongside the hormonal axes that decline with metabolic age.
The master timing network that syncs peripheral clocks. Disrupted by shift work, jet lag and irregular eating — read through cortisol rhythm and thyroid axis.
Chromatin accessibility bridges metabolism to gene expression. Methylation cofactors and hormonal inputs surface epigenetic drift before it compounds.
The master fibrotic switch. When SMAD signaling tips toward the fibrotic arm, tissue lays down scar instead of repair. Read here through standard reference-lab hepatic and renal markers — all contained in the CMP.
The same biomarkers, read two ways. Population ranges flag disease once it arrives. Cascade targets flag the pattern while it's still upstream.
A curated set of biomarkers mapped to one of ten interlinked cellular signaling networks. Instead of testing organs in isolation, each panel reads the upstream signaling pattern that drives a functional domain — such as the PI3K-AKT-mTOR growth axis or the AMPK-Sirtuin-NAD⁺ longevity axis.
These five: Metabolic (PI3K-AKT-mTOR), Longevity (AMPK-Sirtuin-NAD⁺), Fibrosis (TGF-β/SMAD), Circadian (CLOCK/BMAL1), and Epigenetic (HDAC/DNMT). Every biomarker in them is orderable through a standard reference lab — no specialty send-outs. Order codes should be verified for your service area first.
No. Bundled orders cut redundancy: the CMP already contains glucose, AST, ALT, creatinine and eGFR, and the lipid panel covers LDL, HDL and triglycerides. HOMA-IR and eGFR are calculated values, not separate draws.
No. SignalOME is a clinical decision-support scaffold, not an FDA-cleared diagnostic ontology. Results are for educational and clinical-support purposes and should be interpreted by a licensed provider.
Five cascades. One draw. Your baseline starts with a single order.
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